Print Overview Mesentery Enlarge image Close Mesentery Mesentery The mesentery is a fold of membrane that attaches the intestine to the abdominal wall and holds it in place. Mesenteric lymphadenitis is an inflammation of the lymph nodes in the mesentery. Lymphadenitis is a condition in which your lymph nodes become inflamed. When the condition affects the lymph nodes in the membrane that connects your bowel to the abdominal wall (mesentery), it's called mesenteric lymphadenitis (mez-un-TER-ik lim-fad-uh-NIE-tis). A viral intestinal infection is the usual cause of mesenteric lymphadenitis, also known as mesenteric adenitis. It mainly affects children and teens. This painful condition can mimic appendicitis or a condition in which part of the intestine slides into another part of the intestine (intussusception). Unlike appendicitis or intussusception, mesenteric lymphadenitis is seldom serious and usually clears up on its own.Products & ServicesA Book: Mayo Clinic Family Health Book, 5th EditionNewsletter: Mayo Clinic Health Letter — Digital EditionShow more products from Mayo Clinic SymptomsPossible signs and symptoms of mesenteric lymphadenitis include: Abdominal pain, often centered on the lower right side, but the pain can be more widespread General abdominal tenderness Fever Mesenteric lymph node enlargement Depending on what's causing the ailment, signs and symptoms might also include: Diarrhea Nausea and vomiting When to see a doctorAbdominal pain is common in children and teens, and it can be hard to know when it requires medical attention. Call your doctor right away if your child has episodes of: Sudden, severe abdominal pain Abdominal pain with fever Abdominal pain with diarrhea or vomiting In addition, call your doctor if your child has episodes of the following signs and symptoms that don't get better over a short time: Abdominal pain with a change in bowel habits Abdominal pain with loss of appetite Abdominal pain that interferes with sleep CausesThe most common cause of mesenteric lymphadenitis is a viral infection, such as gastroenteritis — often called stomach flu. This infection causes inflammation in the lymph nodes in the thin tissue that attaches your intestine to the back of your abdominal wall (mesentery). Other causes of mesenteric lymphadenitis include bacterial infection, inflammatory bowel disease and lymphoma. By Mayo Clinic Staff Request an appointment Diagnosis & treatment May 20, 2021 Print Show references Hay WW, et al. Viral infections. In: Current Diagnosis & Treatment: Pediatrics. 24nd ed. New York, N.Y.: McGraw-Hill Education; 2018. https://accessmedicine.mhmedical.com. Accessed June 18, 2019. Nauman MI. Causes of acute abdominal pain in children and adolescents. https://www.uptodate.com/contents/search. Accessed June 18, 2019. Helbling R, et al. Acute nonspecific mesenteric lymphadenitis: More than "no need for surgery." BioMed Research International. 2017;Feb. 2:e1. https://www.hindawi.com/journals/bmri/2017/9784565/. Accessed June 18, 2019. Benetti C, et al. Course of acute nonspecific mesenteric lymphadenitis: Single-center experience. European Journal of Pediatrics. 2018;177:243. Ferri FF. Mesenteric adenitis. In: Ferri's Clinical Advisor 2020. Philadelphia, Pa.: Elsevier; 2019. https://www.clinicalkey.com. Accessed June 19, 2019. AAP Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2017-2018. Pediatrics. 2017;140:e20172550. Sullivan JE, et al. Clinical report — Fever and antipyretic use in children. Pediatrics. 2011;127:580. Reaffirmed July 2016. 201.314 labeling of drug preparations containing salicylates. Electronic Code of Federal Regulations. https://www.ecfr.gov/cgi-bin/text-idx?SID=76be002fc0488562bf61609b21a6b11e&mc=true&node=se21.4.201_1314&rgn=div8. Accessed Feb. 22, 2018. Renaud DL (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 27, 2018. Related Associated Procedures Abdominal ultrasound Products & Services A Book: Mayo Clinic Family Health Book, 5th Edition Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Mesenteric lymphadenitisSymptoms&causesDiagnosis&treatment Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. 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